Download Genome Guardian for FREE on PC. Learn how to download and install Genome Guardian for free in this article and be sure to share this site with your friends.

Game Overview

Dive into a microscopic alien world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that’s easy to pick up but hard to master. Research permanent upgrades to survive 70 different microbes across 8 game modes, each with multiple ascension levels (“depths”).

Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!

  • Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
  • Bomb + Bomb doubles down on explosive power to make Bazooka!
  • Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!
  • 49 Turrets with unique strengths and functions
  • 96 Perks to mix and match that drastically change how you play
  • 72 Turret & Weapon Mods that can turn shots into sticky mines or bouncing fireballs
  • 32 Mutations that alter the challenges you face each run
  • 20-minute Runs that can be continued in Endless Mode
  • 60 Bassy Electronic Tunes that adapt to the current mood and intensity
  • 100 Steam Achievements
  • 49 Cosmetics including spider legs, tank tread and a swarm of drones
  • Accessibility Settings for colourblindness and motion sickness
  • Cloud Save
  • Plays great on Steam Deck! (official Steam Deck Compatibility Review pending)

Genome Guardian is a product of passion – a culmination of everything I love about roguelite shooters, and a novel ‘weapon-combining’ feature that I’ve wanted to realize since I was a teenager. Your support will mean content updates and allow me to make more games in the future.

How to Download & Install Genome Guardian

1. Click the Download button below and you will be redirected to crolinks. Wait 5 seconds to generate the link and then proceed to UploadHaven.
2. Once you are on the UploadHaven page, wait 15 seconds, then click on the grey ‘free download’ button to start the download.
3. Once Genome Guardian is done downloading, right click the .zip file and click on “Extract to Genome Guardian” (To do this you must have WinRAR installed.)
4. Double click inside the Genome Guardian folder and run the exe application as administrator.
5. Have fun and play! Make sure to run the game as administrator and if you get any missing dll errors, be sure to install everything located inside the _Redist or CommonRedist folder!

 


Genome Guardian (v4.1.0)
Size: 487.51 MB

 

Download speeds slow? Use Free Download Manager for faster speeds.

If you need any additional help, refer to our Troubleshoot section

YOU MUST HAVE DIRECTX INSTALLED TO AVOID DLL ERRORS.
IF YOU STILL HAVE DLL ERRORS, DOWNLOAD AND INSTALL THE ALL-IN-ONE VCREDIST PACKAGE

NOTICE: MAKE SURE TO HAVE YOUR ANTIVIRUS DISABLED, NOT DOING SO RESULTS INTO THE GAME YOU ARE INSTALLING TO CRASH AND NOT OPEN. ALL DOWNLOAD FILES ON THIS SITE ARE 100% CLEAN, REGARDLESS OF WHAT NORTON, AVG, MCAFEE, ETC… PICKS UP

System Requirements

  • OS: Windows 10
  • Storage: 600 MB available space
  • Additional Notes: Turn down “Render Scale” in settings if framerate is low

Screenshots